Tranexamic acid injections have been added to the Institute for Safe Medication Practices’  (ISMP’s) 2024 List of High-Alert Medications in Acute Care Settings. “High-alert” medications have an increased risk of causing significant harm to patients when they are incorrectly administered. ISMP recommends that practitioners implement safeguarding measures to minimize the risk of error when dispensing these drugs. 

The list was updated based on an ISMP 2023 survey in which 100 practitioners, including pharmacists, nurses, pharmacy technicians, and others, reviewed the ISMP 2018 List of High-Alert Medications in Acute Care Settings to determine if those drugs were still considered high-alert medications in 2023 and submitted feedback on new additions.