To help pharmacists navigate certain social determinants of health (SDOH) that patients may face, the Pharmacy Quality Alliance (PQA) created a resource guide that outlines real-world services that address these issues affecting patients’ abilities to access or manage their medications. Examples of SDOH affecting patients during pharmacy encounters may include: cost of medications; cultural or literacy barriers; decent, safe, and affordable housing; food security; screening for unmet needs; social isolation; and transportation. The PQA guide includes information that pharmacists can employ in their practices to address SDOH, including SDOH screenings and social services referrals. The guide can be downloaded from the PQA website by visiting https://www.pqaalliance.org/sdoh-resource-guide.