The International Pharmaceutical Federation (FIP) has published an updated version of its vaccination reference guide for pharmacists. The 2025 version of the FIP Knowledge and Skills Reference Guide for Professional Development in Vaccination Services expands on the roles of pharmacists in reducing vaccination hesitancy, improving vaccine uptake, and maintaining proper storage, handling, and distribution procedures for vaccines. The guide also identifies areas where pharmacists can enhance their skills and knowledge to continue to be leaders in providing vaccination services, including advances in vaccine technology and supply chain management, navigating digital health systems and leveraging technology, preparing for future health emergencies, and more.