Food and Drug Administration (FDA) approved the Narcan® 4 mg naloxone hydrochloride nasal spray to be sold over-the-counter (OTC), making it the first naloxone product that will be available without a prescription. Naloxone is a life-saving medication that reverses the effects of opioid overdoses. The product will include instructions for consumers regarding how to use the drug safely and effectively without the supervision of a health care professional. While it may take months for the medication to transition from prescription status to OTC, the agency has plans to work with all stakeholders to ensure the continued availability of other naloxone nasal spray products during this time. Additional information is available on FDA’s website under news releases.