Gabapentin, a prescription drug approved by Food and Drug Administration to treat seizures and the pain of shingles, was a factor in about one in 10 United States overdose deaths between 2019 and 2020. Gabapentin is used by some consumers to maximize the effects of opioids but can lead to breathing difficulties when used with drugs that depress the central nervous system, such as opioids, antianxiety medications, and antidepressants. Toxicology tests detected gabapentin in 5,687 overdose deaths between 2019 and 2020, roughly 10% of all cases with test results available, reported Centers for Disease Control and Prevention Division of Overdose Prevention using data from 23 states and the District of Columbia. Most of the deaths caused by gabapentin occurred in white adults aged 35 to 54 years (about 83%).