Food and Drug Administration (FDA) published a notice that the guidance documents addressing the coronavirus disease 2019 (COVID-19) public health emergency (PHE) will no longer be effective after the PHE declaration ends on May 11, 2023. This notice will affect 72 COVID-19-related guidance documents. The agency is expected to monitor and assess the circumstances of the COVID-19 pandemic and alter the COVID-19-related documents, if necessary.