Centers for Disease Control and Prevention (CDC) has published the 2022 CDC Clinical Practice Guideline for Prescribing Opioids for Pain (2022 Clinical Practice Guideline) as part of the Morbidity and Mortality Weekly Report. This clinical tool includes new recommendations to help clinicians and patients weigh the benefits and risks of tapering or continuing opioids, additional details on benefits and risks of nonopioid pain treatments, an expanded focus on health equity, and more. The 2022 Clinical Practice Guideline replaced the 2016 CDC Guideline for Prescribing Opioids for Chronic Pain, and it can be accessed via the CDC website at